An innovative tool to handle somatic and germline TP53 variants.
Users can test a single variant on this page or perform a batch analysis using txt file as well as VCF or MAF file generated by NGS.
Seshat performs the following tasks:
Quality checks mutation nomenclature.
Generates a full description of each variant formatted according to HGVS.
Generates publication-ready tables.
Assesses the pathogenicity of each variant according to the ACMG technical standards and guidelines including general prediction algorithms
MutationAssessor and 7 other algorithms) or algorithms developed exclusively for TP53.
Displays functional and structural data for each TP53 variant.